John Ourand of Sports Business Journal wrote an excellent article on the sports entities of both NBC and Comcast that are needed to make it successful on the sports side.
(As a plug, if you are a sports fan and have any interest in business, economics, etc., SBJ is a must read along with its companion Sports Business Daily.)
John notes that Notre Dame football, currently with NBC until 2015, could have games moved to cable under the contract. Right now, NBC requests that the Irish provide eight games per season and the schedule as of late has been finding more teams from non-AQ conferences on it than in the past (San Diego St. in 2008, Nevada in 2009, Utah and Western Michigan in 2010).
Typically Notre Dame schedules the same five teams each year, arguably these are the Irish's "conference" games:
Michigan (though they are taking a two year break in a couple years so the Irish can do a home-home with Oklahoma)
The Irish also regularly schedules Pittsburgh, Boston College and Stanford. In most years it leaves the Irish with five games to sprinkle about the country. They're supposed to play Big East teams on a regular basis, supposedly three per year, but I've yet to see that put into practice.
Putting the cart way before the horse, I think its entirely possible that if Versus got a chance to pick up ND football, it would get probably two games per year. Likely a one-off game vs. a non-BCS team (like WMU), plus another game where the opponent's record is less than stellar or the opponent is not well known nationally (this year's example might be UConn). I believe NBC would want to retain the neutral site "home" game each year as NBC has stated it would likely use that game as a primetime ND game every year, regardless of the stature of the opponent.